Mapping neutralizing and non-neutralizing epitopes on the capsid protein of feline calicivirus

被引：32

作者：

Geissler, K ^{[1
]}

Schneider, K ^{[1
]}

Truyen, U ^{[1
]}

机构：

[1] Univ Munich, Inst Med Microbiol Infect & Epidem Dis, Munich, Germany

来源：

JOURNAL OF VETERINARY MEDICINE SERIES B-INFECTIOUS DISEASES AND VETERINARY PUBLIC HEALTH | 2002年 / 49卷 / 01期

关键词：

D O I：

10.1046/j.1439-0450.2002.00529.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Neutralizing epitopes on feline calicivirus (FCV) capsid protein were mapped using chimeric capsid proteins recombinant between two FCV isolates that do not show any cross-neutralization. The three chimeric proteins examined were expressed in murine L929 cells employing an MVA/T7 vaccinia virus expression system and inoculated into major histocompatibility complex hapiotype-matched C3/HN mice. Based on the neutralizing antibody titre the neutralizing epitope(s) could be mapped to the 5' hypervariable region of the E region or potentially to the C region. The epitopes of some non-neutralizing antibodies were mapped with the same chimeric proteins to the regions B or D and F of the FCV capsid protein.

引用

页码：55 / 60

页数：6

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