Differential expression of the four untranslated BDNF exons in the adult mouse brain

被引:17
|
作者
Malkovska, I
Kernie, SG
Parada, LF [1 ]
机构
[1] Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Ctr, Kent Waldrep Fdn Ctr Basic Neurosci Res Nerve Gro, Dallas, TX 75390 USA
[3] Univ Texas, SW Med Ctr, Dept Pediat, Dallas, TX USA
关键词
neurotrophin; promoter; hybridization;
D O I
10.1002/jnr.20728
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of secreted proteins and has important functions in the peripheral and central nervous systems (CNS). Its gene organization is complex, comprising four untranslated exons, each with an associated promoter. We have examined the expression of the four untranslated exons in direct comparison to one another and to the fifth BDNF coding exon by in situ hybridization. Other studies have examined untranslated exon expression in several brain regions in response to specific stimuli; however, this is the first detailed study to describe endogenous exon 1-4 expression throughout the adult mouse brain at baseline conditions. The differential expression of the four untranslated exons seen throughout the brain indicates a complex regulation of BDNF. (C) 2005 Wiley-Liss, Inc.
引用
收藏
页码:211 / 221
页数:11
相关论文
共 50 条
  • [1] Differential expression of BDNF exons in rat brain after systemic administration of paroxetine and tranylcypromine
    Khundakar, AA
    Zetterström, TSC
    BRITISH JOURNAL OF PHARMACOLOGY, 2002, 137
  • [2] Differential expression of atypical PKCs in the adult mouse brain
    Oster, H
    Eichele, G
    Leitges, M
    MOLECULAR BRAIN RESEARCH, 2004, 127 (1-2): : 79 - 88
  • [3] Differential expression of BDNF mRNA splice variants in mouse brain and immune cells
    Kruse, Niels
    Cetin, Seray
    Chan, Andrew
    Gold, Ralf
    Luehder, Fred
    JOURNAL OF NEUROIMMUNOLOGY, 2007, 182 (1-2) : 13 - 21
  • [4] Parkin expression in the adult mouse brain
    Stichel, CC
    Augustin, M
    Kühn, K
    Zhu, XR
    Engels, P
    Ullmer, C
    Lübbert, H
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 (12) : 4181 - 4194
  • [5] DIFFERENTIAL EXPRESSION OF CORTICOTROPIN-RELEASING HORMONE IN DEVELOPING MOUSE EMBRYOS AND ADULT BRAIN
    KEEGAN, CE
    HERMAN, JP
    KAROLYI, IJ
    OSHEA, KS
    CAMPER, SA
    SEASHOLTZ, AF
    ENDOCRINOLOGY, 1994, 134 (06) : 2547 - 2555
  • [6] Differential anatomical and cellular expression of lysophosphatidic acid receptor 1 in adult mouse brain
    Kajitani, Naoto
    Okada-Tsuchioka, Mami
    Kano, Kuniyuki
    Omori, Wataru
    Boku, Shuken
    Aoki, Junken
    Takebayashi, Minoru
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 531 (02) : 89 - 95
  • [7] Differential expression of two exclusive exons in the mouse alpha 1(XI) gene.
    Yoshioka, H
    Iyama, K
    Sumiyoshi, H
    Khaleduzzaman, M
    Wu, YL
    Ninomiya, Y
    MATRIX BIOLOGY, 1996, 15 (03) : 164 - 164
  • [8] Plasminogen expression in the neonatal and adult mouse brain
    Basham, ME
    Seeds, NW
    JOURNAL OF NEUROCHEMISTRY, 2001, 77 (01) : 318 - 325
  • [9] Expression of prokineticins and their receptors in the adult mouse brain
    Cheng, Michelle Y.
    Leslie, Frances M.
    Zhou, Qun-Yong
    JOURNAL OF COMPARATIVE NEUROLOGY, 2006, 498 (06) : 796 - 809
  • [10] Expression of neurochondrin in the developing and adult mouse brain
    Istvánffy, R
    Weisenhorn, DMV
    Floss, T
    Wurst, W
    DEVELOPMENT GENES AND EVOLUTION, 2004, 214 (04) : 206 - 209