Family income, parental education and brain structure in children and adolescents

被引：778

作者：

Noble, Kimberly G. ^{[1
,2
]}

Houston, Suzanne M. ^{[3
,4
,5
]}

Brito, Natalie H. ^{[6
]}

Bartsch, Hauke ^{[7
]}

Kan, Eric ^{[4
,5
]}

Kuperman, Joshua M. ^{[8
,9
,10
]}

Akshoomoff, Natacha ^{[10
,11
,12
]}

Amaral, David G. ^{[10
,13
]}

Bloss, Cinnamon S. ^{[10
,14
]}

Libiger, Ondrej ^{[15
]}

Schork, Nicholas J. ^{[16
]}

Murray, Sarah S. ^{[10
,17
]}

Casey, B. J. ^{[10
,18
]}

Chang, Linda ^{[10
,19
]}

Ernst, Thomas M. ^{[10
,19
]}

Frazier, Jean A. ^{[10
,20
]}

Gruen, Jeffrey R. ^{[10
,21
,22
,23
]}

Kennedy, David N. ^{[10
,20
]}

Van Zijl, Peter ^{[10
,24
,25
]}

Mostofsky, Stewart ^{[10
,25
]}

Kaufmann, Walter E. ^{[10
,26
,27
]}

Kenet, Tal ^{[10
,27
,28
]}

Dale, Anders M. ^{[8
,10
,29
,30
,31
]}

Jernigan, Terry L. ^{[10
,11
,12
,29
]}

Sowell, Elizabeth R. ^{[4
,5
,10
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, New York, NY USA

[2] Columbia Univ, Teachers Coll, New York, NY 10027 USA

[3] Univ So Calif, Dept Psychol, Los Angeles, CA 90089 USA

[4] Childrens Hosp, Saban Res Inst, Los Angeles, CA 90027 USA

[5] Univ So Calif, Keck Sch Med, Dept Pediat, Los Angeles, CA 90033 USA

[6] Columbia Univ, Robert Wood Johnson Hlth & Soc Scholar Program, New York, NY 10027 USA

[7] Univ Calif San Diego, Stein Inst Res Aging, San Diego, CA 92103 USA

[8] Univ Calif San Diego, Multimodal Imaging Lab, San Diego, CA 92103 USA

[9] Univ Calif San Diego, Dept Radiol, San Diego, CA 92103 USA

[10] Pediat Imaging Neurocognit & Genet Study, San Diego, CA USA

[11] Univ Calif San Diego, Ctr Human Dev, San Diego, CA 92103 USA

[12] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA

[13] Univ Calif Davis, MIND Inst, Davis, CA 95616 USA

[14] Univ Calif San Diego, Qualcomm Inst, San Diego, CA 92103 USA

[15] MD Revolut Inc, La Jolla, CA USA

[16] Univ Calif San Diego, J Craig Venter Inst, Human Biol, San Diego, CA 92103 USA

[17] Univ Calif San Diego, Dept Pathol, San Diego, CA 92103 USA

[18] Cornell Univ, Weill Med Coll, New York, NY 10021 USA

[19] Univ Hawaii, John A Burns Sch Med, Dept Med, Honolulu, HI 96822 USA

[20] Univ Massachusetts, Sch Med, Worcester, MA 01605 USA

[21] Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06510 USA

[22] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA

[23] Yale Univ, Sch Med, Dept Investigat Med, New Haven, CT 06510 USA

[24] Johns Hopkins Univ, Dept Radiol, Baltimore, MD USA

[25] Kennedy Krieger Inst, Baltimore, MD USA

[26] Boston Childrens Hosp, Dept Neurol, Boston, MA USA

[27] Harvard Univ, Sch Med, Boston, MA 02115 USA

[28] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[29] Univ Calif San Diego, Dept Cognit Sci, San Diego, CA 92103 USA

[30] Univ Calif San Diego, Dept Neurosci, Dept Neurol, San Diego, CA 92103 USA

[31] Univ Calif San Diego, Ctr Translat Imaging & Personalized Med, La Jolla, CA 92093 USA

来源：

NATURE NEUROSCIENCE | 2015年 / 18卷 / 05期

关键词：

SOCIOECONOMIC-STATUS; CORTICAL THICKNESS; CHILDHOOD POVERTY; ASSOCIATIONS; CORTEX; NETWORKS;

D O I：

10.1038/nn.3983

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Socioeconomic disparities are associated with differences in cognitive development. The extent to which this translates to disparities in brain structure is unclear. We investigated relationships between socioeconomic factors and brain morphometry, independently of genetic ancestry, among a cohort of 1,099 typically developing individuals between 3 and 20 years of age. Income was logarithmically associated with brain surface area. Among children from lower income families, small differences in income were associated with relatively large differences in surface area, whereas, among children from higher income families, similar income increments were associated with smaller differences in surface area. These relationships were most prominent in regions supporting language, reading, executive functions and spatial skills; surface area mediated socioeconomic differences in certain neurocognitive abilities. These data imply that income relates most strongly to brain structure among the most disadvantaged children.

引用

页码：773 / +

页数：8

共 50 条

[1] Family income, parental education and brain structure in children and adolescents
Kimberly G Noble
Suzanne M Houston
Natalie H Brito
Hauke Bartsch
Eric Kan
Joshua M Kuperman
Natacha Akshoomoff
David G Amaral
Cinnamon S Bloss
Ondrej Libiger
Nicholas J Schork
Sarah S Murray
B J Casey
Linda Chang
Thomas M Ernst
Jean A Frazier
Jeffrey R Gruen
David N Kennedy
Peter Van Zijl
Stewart Mostofsky
Walter E Kaufmann
Tal Kenet
Anders M Dale
Terry L Jernigan
Elizabeth R Sowell
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