Nano systems and devices for applications in biology and nanotechnology

被引：5

作者：

Perret, G. ^{[1
,2
]}

Ginet, P. ^{[1
]}

Tarhan, M. C. ^{[1
,3
]}

Baccouche, A. ^{[1
,4
]}

Lacornerie, T. ^{[5
]}

Kumemura, M. ^{[1
,3
]}

Jalabert, L. ^{[1
]}

Cleri, F. ^{[2
]}

Lartigau, E. F. ^{[5
]}

Kim, B. J. ^{[1
,3
]}

Karsten, S. L. ^{[6
]}

Fujita, H. ^{[1
,3
]}

Rondelez, Y. ^{[1
,3
]}

Fujii, T. ^{[1
,3
]}

Collard, D. ^{[1
,3
]}

机构：

[1] Univ Tokyo, Inst Ind Sci, LIMMS, CNRS,IIS,UMI 2820,Meguro Ku, Tokyo 1538505, Japan

[2] CNRS, UMR8520, IEMN, F-59652 Villeneuve Dascq, France

[3] Univ Tokyo, Inst Ind Sci, Meguro Ku, Tokyo 1538505, Japan

[4] CNRS, UMR 8601, Lab Chim & Biochim Pharmacol & Toxicol, F-75270 Paris 06, France

[5] Univ Lille 2, Ctr Oscar Lambret, F-59020 Lille, France

[6] NeuroIndx, Signal Hill, CA 90755 USA

来源：

SOLID-STATE ELECTRONICS | 2016年 / 115卷

关键词：

MEMS; Tweezers; Nanowire; Molecular motor; Molecular programming; DNA; SILICON; TRANSPORT; DESIGN;

D O I：

10.1016/j.sse.2015.08.019

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Micro and nano systems (MNS) and Nano scaled devices, that are capable of handling fluids and to interact with DNA and proteins enable bio analysis at the "ultimate" molecular level and are prone to be coupled to IC Technology. This paper includes recent developments in this area, aimed at illustrating the diversity and potential of the MNS approach: (1) micromachined tweezers with sharp tips successfully captured a bundle of DNA molecules, allowing real-time observation of DNA degradation dynamics under therapeutic irradiations; (2) a simple method to fabricate FET silicon nanowires using only standard micro-electromechanical system (MEMS) processes is able to perform molecular level medical diagnosis; (3) a bio motor system, composed by microtubules and kinesin, reconstructed on a chip, can distinguish normal and abnormal tau-proteins related to Alzheimer's disease; and (4) an advanced concept of molecular programing in which real molecular interactions emulate partial different equations and are able to solve complex systems such as a predator-prey ecosystem. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：66 / 73

页数：8

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