Optical Control of TRPV1 Channels

被引：46
|
作者：
Stein, Marco [1 ,2 ]
Breit, Andreas [3 ]
Fehrentz, Timm [1 ,2 ]
Gudermann, Thomas [3 ]
Trauner, Dirk [1 ,2 ]
机构：
[1] Univ Munich, Dept Chem, D-81377 Munich, Germany
[2] Ctr Integrated Prot Sci, D-81377 Munich, Germany
[3] Ludwig Maximilians Univ Munchen, Walther Straub Inst Pharmacol & Toxicol, D-80336 Munich, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 37期
关键词：
azobenzenes; capsaicin; capsazepine; photopharmacology; TRPV1; IONOTROPIC GLUTAMATE RECEPTORS; CAPSAICIN RECEPTOR; ION-CHANNEL; VISUAL RESPONSES; ACTIVATION; RESINIFERATOXIN; PHOTOSWITCH; CAPSAZEPINE; ANTAGONIST; ANANDAMIDE;
D O I：
10.1002/anie.201302530
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Controlling pain with light: TRPV1 channels mediate the response to noxious heat and can be activated by capsaicin, the major ingredient of chili pepper. Novel azobenzene photoswitches can be used for the optical control of TRPV1. One of these compounds antagonizes capsaicin in a light-dependent fashion, demonstrating that a photoswitchable antagonist and an agonist can be applied in concert to modulate ion channel activity. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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页码：9845 / 9848
页数：4
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