Resveratrol reverts Streptozotocin-induced diabetic nephropathy

被引：12
|
作者：
Zhu, Huiping [1 ,2 ]
Zhong, Sen [1 ,2 ]
Yan, Haihong [1 ,2 ]
Wang, Kangyao [1 ,2 ]
Chen, Lingwei [1 ,2 ]
Zhou, Min [1 ,2 ]
Li, Yunsheng [1 ,2 ]
机构：
[1] Wenzhou Med Univ, Peoples Hosp Wenling 1, Dept Nephrol, 333 Chuanan Rd, Wenling 317500, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Affiliated Wenling Hosp, 333 Chuanan Rd, Wenling 317500, Zhejiang, Peoples R China
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2020年 / 25卷
关键词：
Resveratrol; Renal dysfunction; Diabetic nephropathy; mTOR/ULK1; pathway; Autophagy; RENAL LIPID-METABOLISM; PODOCYTE FUNCTION; AUTOPHAGY; MICE; ACCUMULATION; PROGRESSION; PROTECTS; FIBROSIS; TARGET; MTOR;
D O I：
10.2741/4829
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diabetes causes diabetic nephropathy (DN) which is associated with increased morbidity and mortality in diabetic patients. We tested whether Resveratrol (Res) reverses the systemic effect of Streptozotocin (STZ) induced diabetes and DN. Res treatment opposed the effect of STZ on kidney weight, 24 h urinary albumin excretion, blood urea nitrogen (BUN) and serum creatinine (Scr). Res also decreased DN induced mTOR/ULK1-mediated autophagy and apoptosis and significantly reduced STZ mediated lipid deposition in nephrons, likely by decreasing the levels of lipogenic related proteins (SREBP-1c, ACS) and increased lipidolysis related proteins (PPAR alpha, CPT-1). Together, these findings show the potential of Res in prevention of diabetic nephropathy.
引用
收藏
页码：699 / 709
页数：11
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