A new system for multiplexed mosaic analysis of gene function in the mouse

被引：0
|
作者：
Cai, Hongchen [1 ]
Winslow, Monte M. [1 ,2 ]
机构：
[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
来源：
CELL REPORTS METHODS | 2022年 / 2卷 / 09期
关键词：
D O I：
10.1016/j.crmeth.2022.100295
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
In a recent issue of Cell, Liu et al. present an innovative mouse model system in which Cre/lox stochastically turns on transgenic expression of one out of up to 100 sgRNAs in somatic cells, creating genetic mosaicism that enables the multiplexed assessment of gene function in vivo.
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页数：3
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