Akt inhibitor MK2206 selectively targets CLL B-cell receptor induced cytokines, mobilizes lymphocytes and synergizes with bendamustine to induce CLL apoptosis

被引：19
|
作者：
Ding, Wei [1 ]
Shanafelt, Tait D. [1 ]
Lesnick, Connie E. [1 ]
Erlichman, Charles [1 ]
Leis, Jose F. [2 ]
Secreto, Charla [1 ]
Sassoon, Traci R. [1 ]
Call, Timothy G. [1 ]
Bowen, Deborah A. [1 ]
Conte, Michael [1 ]
Kumar, Shaji [1 ]
Kay, Neil E. [1 ]
机构：
[1] Mayo Clin, Rochester, MN USA
[2] Mayo Clin, Scottsdale, AZ USA
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2014年 / 164卷 / 01期
关键词：
chronic lymphocytic leukaemia; Akt; B cell receptor; cytokine; LEUKEMIA; EXPRESSION; TRIAL;
D O I：
10.1111/bjh.12564
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：146 / 150
页数：5
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