Tuning nano electric field to affect restrictive membrane area on localized single cell nano-electroporation

被引：27
|
作者：
Santra, Tuhin Subhra [1 ]
Wang, Pen-Cheng [2 ]
Chang, Hwan-You [3 ]
Tseng, Fan-Gang [1 ,2 ,3 ,4 ]
机构：
[1] Natl Tsing Hua Univ, Inst Nano Engn & Microsyst, Hsinchu, Taiwan
[2] Natl Tsing Hua Univ, Dept Engn & Syst Sci, Hsinchu, Taiwan
[3] Natl Tsing Hua Univ, Dept Med Sci, Hsinchu, Taiwan
[4] Acad Sinica, Div Mech, Res Ctr Appl Sci, Taipei 115, Taiwan
来源：
APPLIED PHYSICS LETTERS | 2013年 / 103卷 / 23期
关键词：
MAMMALIAN-CELLS; GENE-TRANSFER;
D O I：
10.1063/1.4833535
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
Interaction of electric field with biological cells is an important phenomenon for field induced drug delivery system. We demonstrate a selective and localized single cell nano-electroporation (LSCNEP) by applying an intense electric field on a submicron region of the single cell membrane, which can effectively allow high efficient molecular delivery but low cell damage. The delivery rate is controlled by adjusting transmembrane potential and manipulating membrane status. Thermal and ionic influences are deteriorated from the cell membrane by dielectric passivation. Either reversible or irreversible by LSCNEP can fully controlled with potential applications in medical diagnostics and biological studies. (C) 2013 AIP Publishing LLC
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页数：5
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