Manganese(ii)-catalysed dehydrogenative annulation involving C-C bond formation: highly regioselective synthesis of quinolines

被引：13
|
作者：
Wang, Chengniu [1 ]
Yang, Jinfei [1 ]
Meng, Xiao [1 ]
Sun, Yufeng [1 ]
Man, Xuyan [1 ]
Li, Jinxia [1 ]
Sun, Fei [1 ]
机构：
[1] Nantong Univ, Inst Reprod Med, Med Sch, Nantong 226019, Peoples R China
来源：
DALTON TRANSACTIONS | 2019年 / 48卷 / 14期
基金：
中国国家自然科学基金;
关键词：
H ACTIVATION; CATALYZED ARYLATION; COPPER; FUNCTIONALIZATION; PALLADIUM; ALKYNES; ALKENYLATION; ALKYLATIONS; SELECTIVITY; INSERTION;
D O I：
10.1039/c9dt00647h
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
An inexpensive nontoxic manganese(ii)-catalysed dehydrogenative annulation was developed for C-C bond formation. The reaction showed high selectivity and efficiency across a broad substrate scope. Remarkably simple conditions and the ability to conduct gram-scale synthesis underscore this method's utility. To demonstrate the potential of this approach, we tested the drug effects of compound 3n, which showed activity for blocking vascular development. The results of this study will be important for the treatment of eye diseases and tumors caused by vascular proliferation.
引用
收藏
页码：4474 / 4478
页数：5
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