Rhodamine-Functionalized Graphene Quantum Dots for Detection of Fe3+ in Cancer Stem Cells

被引：163
|
作者：
Guo, Ruihua [1 ]
Zhou, Shixin [2 ]
Li, Yunchao [1 ]
Li, Xiaohong [1 ]
Fan, Louzhen [1 ]
Voelcker, Nicolas H. [3 ]
机构：
[1] Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China
[2] Peking Univ, Hlth Sci Ctr, Sch Basic Med, Dept Cell Biol, Beijing 100191, Peoples R China
[3] Univ S Australia, ARC Ctr Excellence Convergent Bionano Sci & Tech, Mawson Lakes, SA 5095, Australia
来源：
ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 43期
基金：
澳大利亚研究理事会;
关键词：
graphene quantum dots; rhodamine B derivative; detection; Fe3+; cancer stem cells; FLUORESCENT SENSING PLATFORM; IRON REGULATORY PROTEINS; LABEL-FREE DETECTION; FACILE SYNTHESIS; SELECTIVE DETECTION; CARBON NANODOTS; UP-CONVERSION; PROBE; NANOPARTICLES; CHEMOSENSORS;
D O I：
10.1021/acsami.5b06523
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
A turn-on orange-red fluorescent nanosensor based on rhodamine B derivative-functionalized graphene quantum dots (RBD-GQDs) has been successfully synthesized for Fe3+ detection with high sensitivity and selectivity. By connecting with GQDs, the water solubility, sensitivity, photostability, and biocompatibility of RBD are drastically improved. The most distinctive feature of the RBD-GQDs, which sets them apart from other previously reported fluorophores or GQDs, is that they with the detection limits as low as 0.02 mu M are demonstrated as a Fe3+ turn-on fluorescent nanosensor in cancer stem cells. Fe3+ binding to such GQDs (RBD-GQDs-Fe3+) with orange-red fluorescence of 43% quantum yield were demonstrated to be the biomarkers for cancer stem cell imaging.
引用
收藏
页码：23958 / 23966
页数：9
相关论文
共 50 条
  • [1] Portable quantitative detection of Fe3+ by integrating a smartphone with colorimetric responses of a rhodamine-functionalized polyacrylamide hydrogel chemosensor
    Liu, Xueyan
    Chen, Zhuo
    Gao, Rongsheng
    Kan, Chengyou
    Xu, Jianhong
    SENSORS AND ACTUATORS B-CHEMICAL, 2021, 340 (340):
  • [2] Electrochemical Trimming of Graphene Oxide Affords Graphene Quantum Dots for Fe3+ Detection
    Qiang, Ruibin
    Sun, Weiming
    Hou, Kaiming
    Li, Zhangpeng
    Zhang, Jinyun
    Ding, Yong
    Wang, Jinqing
    Yang, Shengrong
    ACS APPLIED NANO MATERIALS, 2021, 4 (05) : 5220 - 5229
  • [3] D-penicillamine-functionalized graphene quantum dots for fluorescent detection of Fe3+ in iron supplement oral liquids
    Wang Xuan
    Li Ruiyi
    Fan Saiying
    Li Zaijun
    Wang Guangli
    Gu Zhiguo
    Liu Junkang
    SENSORS AND ACTUATORS B-CHEMICAL, 2017, 243 : 211 - 220
  • [4] Synthesis of high fluorescence graphene quantum dots and their selective detection for Fe3+ in aqueous solution
    Xu, Ting-Ting
    Yang, Jia-Xiang
    Song, Ji-Ming
    Chen, Jing-Shuai
    Niu, He-Lin
    Mao, Chang-Jie
    Zhang, Sheng-Yi
    Shen, Yu-Hua
    SENSORS AND ACTUATORS B-CHEMICAL, 2017, 243 : 863 - 872
  • [5] Amino-functionalized graphene quantum dots prepared using high-softening point asphalt and their application in Fe3+ detection
    Wang, Ruyi
    Fan, Huailin
    Jiang, Wei
    Ni, Guosong
    Qu, Shijie
    APPLIED SURFACE SCIENCE, 2019, 467 : 446 - 455
  • [6] Selective detection of Hg2+ using fluorescent rhodamine-functionalized Fe3O4 nanoparticles
    Kim, Kyung Tae
    Jung, Hyo Sung
    Ahn, Junho
    Choi, Yeonweon
    Jung, Jong Hwa
    Park, Junboum
    RSC ADVANCES, 2016, 6 (83) : 79405 - 79409
  • [7] One-step preparation of single-layered graphene quantum dots for the detection of Fe3+
    Wang, Haogiang
    Wu, Xingxing
    Dong, Weilong
    Lee, Shern-Long
    Yuan, Qunhui
    Gan, Wei
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2020, 226
  • [8] Ultrasensitive Detection of Fe3+ Ions Using Functionalized Graphene Quantum Dots Fabricated by a One-Step Pulsed Laser Ablation Process
    Kang, Sukhyun
    Han, Hyuksu
    Lee, Kangpyo
    Kim, Kang Min
    ACS OMEGA, 2022, 7 (02): : 2074 - 2081
  • [9] A tough fluorescent nanocomposite hydrogel probe based on graphene quantum dots for the selective detection of Fe3+ ions
    Du, Juan
    Zhu, Wenli
    She, Xiaohong
    Yu, Qiyu
    Yang, Qiaoling
    Huang, Huiping
    Tsou, Chihui
    Manuel, De Guzman
    MATERIALS ADVANCES, 2022, 3 (20): : 7579 - 7589
  • [10] Enhanced performance of Fe3+ detection via fluorescence resonance energy transfer between carbon quantum dots and Rhodamine B
    Hu, Shengliang
    Zhao, Qing
    Chang, Qing
    Yang, Jinlong
    Liu, Jun
    RSC ADVANCES, 2014, 4 (77) : 41069 - 41075
12345