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Marineosins A and B, Cytotoxic Spiroaminals from a Marine-Derived Actinomycete

被引：90
|
作者：
Boonlarppradab, Chollaratt [1 ]
Kauffman, Christopher A. [1 ]
Jensen, Paul R. [1 ]
Fenical, William [1 ]
机构：
[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 24期
关键词：
D O I：
10.1021/ol8020644
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two novel spiroaminals, marineosins A and B (1, 2), containing two pyrrole functionalities, were isolated from cultures of a marine sediment-derived actinomycete related to the genus Streptomyces. The marineosins, which appear to be derived from unknown modifications of prodigiosin-like pigment pathways, showed significant inhibition of human colon carcinoma (HCT-116) in an in vitro assay (IC50 = 0.5 mu M for marineosin A) and selective activities in diverse cancer cell types.
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收藏
页码：5505 / 5508
页数：4
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