The Amyloid-β Oligomer Count in Cerebrospinal Fluid is a Biomarker for Alzheimer's Disease

被引：56
|
作者：
Wang-Dietrich, Lei [1 ]
Funke, Susanne Aileen [1 ]
Kuehbach, Katja [1 ]
Wang, Kun [1 ]
Besmehn, Astrid [2 ]
Willbold, Sabine [2 ]
Cinar, Yeliz [1 ]
Bannach, Oliver [3 ]
Birkmann, Eva [1 ,3 ]
Willbold, Dieter [1 ,3 ]
机构：
[1] Forschungszentrum Julich, Inst Complex Syst, D-52425 Julich, Germany
[2] Forschungszentrum Julich, ZCH, D-52425 Julich, Germany
[3] Univ Dusseldorf, Inst Phys Biol, Dusseldorf, Germany
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2013年 / 34卷 / 04期
关键词：
Alzheimer disease; amyloid-beta peptide; early diagnosis; sFIDA; surface based fluorescence intensity distribution analysis; FLUORESCENCE CORRELATION SPECTROSCOPY; COGNITIVE IMPAIRMENT; PRION PARTICLES; PROTEIN; DIAGNOSIS; SAMPLES; PRECURSOR; PATHOLOGY; PEPTIDES; RECEPTOR;
D O I：
10.3233/JAD-122047
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Recent studies indicate that small amyloid-beta peptide (A beta) oligomers are the major toxic species responsible for development and progression of Alzheimer's disease (AD). Therefore, we suggest that the number of A beta oligomers in body fluids is the most direct and relevant biomarker for AD. Determination of the A beta oligomer content of cerebrospinal fluid (CSF) samples from 14 AD patients and 12 age-matched controls revealed a clear distinction between both groups. All samples of the control group showed homogenously low numbers of A beta oligomers, while the samples of the AD group exhibited significantly higher levels of A beta oligomers. The A beta oligomer numbers correlated with the patients' Mini-Mental State Examination scores. This indicates that the quantity of A beta oligomers in CSF reflects the severity of the disease and that A beta oligomers play a crucial role in AD pathology and in turn can be used as a diagnostic biomarker.
引用
收藏
页码：985 / 994
页数：10
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