New non-cytotoxic approaches to ovarian cancer

被引：4
|
作者：
Kaye, SB
Eisenhauer, EA
Hamilton, TC
机构：
[1] Univ Glasgow, CRC, Dept Med Oncol, Glasgow G61 1BD, Lanark, Scotland
[2] Queens Univ, NCIC Clin Trials Grp, Kingston, ON K7L 3N6, Canada
[3] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
来源：
ANNALS OF ONCOLOGY | 1999年 / 10卷
关键词：
drug resistance; genetic therapy; immunotherapy; metalloproteinase inhibitors; radioconjugates; signal transduction;
D O I：
10.1023/A:1008315603401
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Two recent examples of conventional cytotoxic drugs, taxoids and topo I inhibitors, are set to make a real impact in the treatment of ovarian cancer. However, further progress may depend on novel approaches, focusing on other targets. This review will concentrate on those approaches which have already led to the initiation of clinical trials: agents designed to circumvent cellular drug resistance, signal transduction inhibitors, new hormonal agents, matrix metalloproteinase inhibitors, immunotherapy, immunotoxins and radioconjugates, and intraperitoneal genetic therapy, including the use of replicating viruses. In some cases, early clinical data are encouraging, but ultimately combined treatment with conventional agents may make most impact.
引用
收藏
页码：65 / 68
页数：4
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