Synthesis and anti-hypertensive activity of novel sulphadimidine derivatives

被引：7

作者：

Gouda, Moustafa A. ^{[1
]}

Gafer, Hatem E. ^{[2
]}

Gouda, Mohamed ^{[2
]}

机构：

[1] Mansoura Univ, Fac Sci, Dept Chem, Mansoura 35516, Egypt

[2] Natl Res Ctr, Text Res Div, Cairo, Egypt

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 11期

关键词：

Pyrimidine; Sulphadimidine dyes; Anti-hypertensive activity; PROTEIN-KINASE-C; HYPERTENSIVE-RATS; SALT;

D O I：

10.1007/s00044-011-9935-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel sulphadimidine derivatives has been synthesized via coupling of sulphadimidine diazonium salt with N-substituted anilines in acetic acid and subjected to evaluate their antihypertensive activity. All the synthesized compounds have similar effects and non-significantly different than the standard drug (Prazosin) and control groups. All newly synthesized dyes were characterized by elemental analyses and spectral data (IR, H-1-NMR, and MS).

引用

页码：3902 / 3906

页数：5

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