Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline

被引:92
|
作者
Beydoun, May A. [1 ]
Boueiz, Adel [2 ]
Abougergi, Marwan S. [2 ]
Kitner-Triolo, Melissa H.
Beydoun, Hind A. [3 ]
Resnick, Susan M.
O'Brien, Richard [4 ]
Zonderman, Alan B.
机构
[1] NIA, NIH, Biomed Res Ctr, IRP, Baltimore, MD 21224 USA
[2] Johns Hopkins Univ, Sch Med, Dept Internal Med, Baltimore, MD USA
[3] Eastern Virginia Med Sch, Grad Program Publ Hlth, Norfolk, VA 23501 USA
[4] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
关键词
Apolipoprotein E genotype; Dementia; Cognitive decline; Cognitive impairment; Aging; DWELLING ELDERLY INDIVIDUALS; ALZHEIMERS-DISEASE; E GENOTYPE; APOE GENOTYPE; OLDER-ADULTS; POPULATION-SAMPLE; EPISODIC MEMORY; HEALTH; AGE; APOE-EPSILON-4;
D O I
10.1016/j.neurobiolaging.2010.05.017
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
We examined longitudinal associations between the apolipoprotein E epsilon 4 allele (ApoE4(+) status) and several cognitive outcomes and tested effect modification by sex. Data on 644 non-Hispanic Caucasian adults, from the Baltimore Longitudinal Study of Aging (BLSA) were used. Dementia onset, cognitive impairment and decline were assessed longitudinally. After 27.5 years median follow-up, 113 participants developed dementia. ApoE4(+) predicted dementia significantly (hazard ratio [HR] = 2.89; 95% confidence interval [CI], 1.93-4.33), with nonsignificant sex differences. Taking all time points for predicting cognition, women had significantly stronger positive associations than men between ApoE4(+) status and impairment or decline on the California Verbal Learning Test (CVLT; delayed recall and List A total recall) and on Verbal Fluency Test-Categories. This ApoE4 x sex interaction remained significant with Bonferroni correction only for CVLT-delayed recall. Taking time points prior to dementia for cognitive predictions, the positive association between impairment in CVLT-delayed recall and ApoE4(+) status remained stronger among women, though only before Bonferroni correction. While ApoE4+ status appears to be a sex neutral risk factor for dementia, its association with verbal memory and learning decline and impairment was stronger among women. Published by Elsevier Inc.
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页数:16
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