Design and development of practical asymmetric syntheses of drug candidates

被引：9
|
作者：
Shinkai, I
机构：
[1] Merck Research Laboratories, PO Box 2000, Rahway, New Jersey
来源：
PURE AND APPLIED CHEMISTRY | 1997年 / 69卷 / 03期
关键词：
D O I：
10.1351/pac199769030453
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Recent progress in asymmetric syntheses has made a significant impact on strategies for drug development in the pharmaceutical industry. Under the recent guidelines by the Food and Drug Administration (FDA), many drug firms are no longer considering the development of racemic forms of chiral drugs. This lecture presents a few examples of highly practical stereoselective syntheses of drug candidates, shown below, discovered and developed at Merck Research Laboratories.
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页码：453 / 458
页数：6
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