Epigenetic modifications in the accumulation and function of myeloid-derived suppressor cells

被引：7
|
作者：
Xu, Liangjie [1 ]
Zhou, Cuicui [1 ]
Liang, Yi [1 ]
Fan, Tinpan [1 ]
Zhang, Fen [1 ]
Chen, Xinxin [1 ]
Yuan, Wei [1 ]
机构：
[1] Jiangsu Univ, Affiliated Hosp, Dept Cardiol, Zhenjiang, Jiangsu, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷
关键词：
epigenetic modification; myeloid-derived suppressor cells; DNA methylation; histone acetylation; N6-methylation; ubiquitination; HISTONE DEACETYLASE 11; DNA METHYLATION; EXPRESSION; ACTIVATION; DEMETHYLATION; ACETYLATION; REVEALS; COMPLEX; LEADS; STAT3;
D O I：
10.3389/fimmu.2022.1016870
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Myeloid-derived suppressor cells (MDSCs) are key players under various pathologic conditions, such as cancer. Epigenetic modifications such as DNA methylation, RNA-mediated processes, and histone modification can alter gene transcription, and thus regulating pathological process. Studies have shown that epigenetic modification contributes to the accumulation and function of MDSCs. This review summarizes the crosstalk between the epigenetic alterations and MDSCs functions, and briefly introduces how the accumulation and function of MDSCs caused by epigenetic modification impact on the disease development, which represents as a promising therapeutic strategy for the related disorders.
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页数：8
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