FGFR Fusions in the Driver's Seat

被引：6

作者：

Sabnis, Amit J. ^{[1
,3
]}

Bivona, Trever G. ^{[2
,3
]}

机构：

[1] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Med, Div Hematol & Oncol, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA

来源：

CANCER DISCOVERY | 2013年 / 3卷 / 06期

关键词：

LUNG-CANCER; GENE;

D O I：

10.1158/2159-8290.CD-13-0185

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Through a clinical deep sequencing protocol, Wu and colleagues have identified multiple FGFR fusion proteins in diverse cancers. Pharmacologic inhibition of FGFR suppressed the growth of FGFR fusion-positive tumor models, suggesting that these FGFR fusions are oncogenic drivers and highlighting the use of streamlined clinical sequencing efforts to identify novel, actionable driver oncoproteins in human tumors.

引用

页码：607 / 609

页数：3

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