Introduction: We present the short-term voiding patterns and functional and urodynamic outcomes of W-shaped ileal orthotopic neobladder (ONB) following radical cystectomy (RC). Materials and Methods: Forty-one patients who underwent RC and W-shaped ONB creation between July 2015 and January 2018 were enrolled. Data were analyzed in terms of voiding patterns, urodynamic findings, and functional outcomes at 6 months after surgery. Pouch-related quality of life (QoL) was assessed using European Organization for Research and Treatment of Cancer (EORTC) Generic (QLQC30), Bladder Cancer-Specific Instruments (QLQBM30), and IONB-Patient-Reported Outcome (IONB-PRO). Results: The mean length of follow-up was 19.4 months. At first follow-up, three patients had developed acidosis and rising serum creatinine, and one of them required temporary hemodialysis. One patient developed urethral-pouch anastomotic stricture, which required bladder neck incision. Balloon dilatation was performed for ureteroileal anastomotic stricture and mesh repair for incisional hernia was required in one patient each. Upper tract changes were observed in two patients. During the first and second follow-up, maximum flow rate, voided volume, and postvoid residual urine were 12 +/- 4.7 mL/s, 212 +/- 120 mL, and 72 +/- 81 mL and 14.7 +/- 5.3 mL/s, 254 +/- 168 mL, and 123.7 +/- 42.5 mL, respectively. The mean pouch capacity and compliance were 436 +/- 103.5 mL and 50.6 +/- 17.8 mL/cm H2O. No patient required clean intermittent catheterization for bladder emptying. In EORTC QLQ-C30 questionnaire, the "Cognitive" domain had the highest and "global QoL" domain had the lowest level of functional scores. "Nausea and vomiting and abdominal bloating and flatulence" domain had the lowest level and "financial difficulties and urinary symptoms" had the highest level of symptomatology in EORTC QLQ questionnaire. The IONS-PRO questionnaire showed the highest level of functioning in "relation life" and the lowest level in "emotional life" domain. Conclusion: The Ghoneim pouch has a low complication rate with near-normal voiding patterns with an acceptable QoL impairment.
