Factors influencing hepatocellular carcinoma prognosis after hepatectomy: a single-center experience

被引:20
|
作者
Park, Sung Keun
Jung, Young Kul
Chung, Dong Hae
Kim, Keon Kuk
Park, Yeon Ho
Lee, Jung Nam
Kwon, Oh Sang
Kim, Yun Soo
Choi, Duck Joo
Kim, Ju Hyun
机构
[1] Department of Internal Medicine, Gachon University Gil Medical Center, Incheon
[2] Department of Pathology, Gachon University Gil Medical Center, Incheon
[3] Department of Surgery, Gachon University Gil Medical Center, Incheon
来源
KOREAN JOURNAL OF INTERNAL MEDICINE | 2013年 / 28卷 / 04期
关键词
MICROVASCULAR INVASION; LIVER-TRANSPLANTATION; RESECTION; CANCER; VALIDATION; MANAGEMENT; RECURRENCE; CRITERIA; JAPAN;
D O I
10.3904/kjim.2013.28.4.428
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background/Aims: Recurrence after hepatic resection is one of the most important factors impacting the prognosis and survival of patients with hepatocellular carcinoma (HCC). We identified prognostic factors affecting overall survival (OS) and disease-free survival (DFS) in patients with HCC after hepatic resection. Methods: This study was of a retrospective cohort design, and 126 patients who underwent hepatic resection for HCC at Gachon University Gil Medical Center between January 2005 and December 2010 were enrolled. Various clinical, laboratory, and pathological data were evaluated to determine the prognostic factors affecting OS and DFS. Results: Two- and 4-year OS and 2- and 4-year UPS were 78.1% and 65% and 51.1% and 26.6%, respectively. In a multivariate analysis, preoperative alpha-fetoprotein (> 400 ng/mL), tumor size (>= 5 cm), multiple tumors (two or more nodules), presence of portal vein invasion, modified Union for International Cancer Control (UICC) stage III/IV, and Barcelona Clinic Liver Cancer (BCLC) stage B/C were independent prognostic factors affecting a shorter OS. In the multivariate analysis, presence of microvascular invasion, modified UICC stage III/IV, and BCLC stage B/C were independent prognostic factors for a shorter DFS. Conclusions: The presence of vascular invasion was an independent poor prognostic factor for OS and DFS in patients with HCC after hepatic resection. Thus, close postoperative surveillance for early detection of recurrence and additional treatments are urgently needed in patients with vascular invasion after hepatic resection.
引用
收藏
页码:428 / 438
页数:11
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