Environmental factors and the age at onset in first episode psychosis

被引:26
|
作者
O'Donoghue, Brian [1 ,2 ]
Lyne, John [3 ,4 ]
Madigan, Kevin [2 ,5 ]
Lane, Abbie [4 ]
Turner, Niall [3 ]
O'Callaghan, Eadbhard [3 ,4 ]
Clarke, Mary [3 ,4 ]
机构
[1] Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia
[2] Natl Ctr Excellence Youth Mental Hlth, Orygen, Melbourne, Vic 3052, Australia
[3] DETECT Early Intervent Psychosis Serv, Dublin 4, Ireland
[4] Univ Coll Dublin, Dublin 4, Ireland
[5] Royal Coll Surgeons Ireland, Inst Leadership, Dublin 2, Ireland
关键词
Psychosis; Age at onset; Environmental; Cannabis; Migration; ANTERIOR CINGULATE CORTEX; OF-ONSET; SCHIZOPHRENIA; RISK; UPDATE; METAANALYSIS; HYPOTHESIS; DISORDERS; GLUTAMATE; ILLNESS;
D O I
10.1016/j.schres.2015.07.004
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: Factors that influence the age at onset in psychotic disorders could provide valuable insights into precipitating or causative factors of the disorder. Despite being established risk factors, it is not yet known whether migration status, place of birth, social class at birth and season of birth influence the age at onset of psychotic disorders. This study aimed to determine whether these environmental factors, in addition to cannabis abuse and obstetric complications, influence the age at onset. Additionally, we investigated whether environmental factors could have a cumulative effect on the age at onset. Method: Data was obtained from two first episode of psychosis (FEP) cohort studies. Diagnosis was established using the Structured Clinical Interview for DSM IV diagnoses. Results: The age at onset was determined for 555 individuals with a FEP and the median age at onset was 27.3 years. Individuals with a history of cannabis abuse had an earlier age at onset by nearly six years. There was a trend for a history of obstetric complications to be associated with a younger age at onset by 2.7 years and this was significant in the subgroup with a family history of psychosis. Social class at birth, migration status, place of birth and season of birth were not associated with the age at onset. Exposure to a higher number of environmental factors was associated with an earlier age at onset. Conclusions: Cannabis and obstetric complications are associated with an earlier age at onset and there appears to be a cumulative effect of exposure to multiple environmental factors. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:106 / 112
页数:7
相关论文
共 50 条
  • [1] AGE OF ONSET IN FIRST EPISODE PSYCHOSIS: THE INFLUENCE AND INTERACTIONS OF THE ENVIRONMENTAL RISK FACTORS
    O'Donoghue, Brian N.
    Lyne, John P.
    Roche, Eric
    Turner, Niall
    O'Callaghan, Eadbhard
    Clarke, Mary
    Lane, Abbie
    SCHIZOPHRENIA RESEARCH, 2012, 136 : S220 - S220
  • [2] CANNABIS USE DISORDERS AND AGE AT ONSET OF PSYCHOSIS IN 606 PATIENTS WITH FIRST EPISODE PSYCHOSIS
    Schimmelmann, B.
    Kupferschmid, S.
    Conus, P.
    Cotton, S.
    McGorry, P.
    Lambert, M.
    EUROPEAN PSYCHIATRY, 2011, 26
  • [3] Age of Onset of Negative Symptoms in a Youth Population With First Episode Psychosis'
    Lyne, John
    O'Donoghue, Brian
    Roche, Eric
    Behan, Caragh
    Jordan, Iain
    Renwick, Laoise
    Turner, Niall
    O'Callaghan, Eadbhard
    Clarke, Mary
    EARLY INTERVENTION IN PSYCHIATRY, 2016, 10 : 88 - 88
  • [4] CANNABIS USE AND AGE OF ONSET IN FIRST EPISODE OF PSYCHOSIS: A GENDER ISSUE?
    Allegri, Fabio
    SCHIZOPHRENIA RESEARCH, 2012, 136 : S25 - S25
  • [5] Cognitive function in first episode psychosis: Effects of gender and age of onset
    Barrett, SL
    Mulholland, C
    Cooper, S
    Rushe, TM
    JOURNAL OF PSYCHOPHARMACOLOGY, 2005, 19 (05) : A14 - A14
  • [6] Birth weight and obstetric complications determine age at onset in first episode of psychosis
    Rubio-Abadal, E.
    Ochoa, S.
    Barajas, A.
    Banos, I.
    Dolz, M.
    Sanchez, B.
    Del Cacho, N.
    Carlson, J.
    Huerta-Ramos, E.
    Usall, J.
    JOURNAL OF PSYCHIATRIC RESEARCH, 2015, 65 : 108 - 114
  • [7] Birth Weight and Obstetric Complications Determine Age at Onset in First Episode of Psychosis
    Rubio-Abadal, E.
    Ochoa, S.
    Barajas, A.
    Bano, I.
    Del Cacho, N.
    Dolz, M.
    Sanchez, B.
    Usall, J.
    EUROPEAN PSYCHIATRY, 2015, 30
  • [8] Influence of Trauma Exposure on Age of Onset and Cognitive Performance in First Episode Psychosis
    Mayoral, Maria
    Muro-Pastrana, Monica
    Roldan, Laura
    Parellada, Mara
    Rodriguez-Toscano, Elisa
    EARLY INTERVENTION IN PSYCHIATRY, 2018, 12 : 130 - 130
  • [9] Neighbourhood-level socio-environmental factors and incidence of first episode psychosis by place at onset in rural Ireland: The Cavan-Monaghan First Episode Psychosis Study [CAMFEPS]
    Omer, Sami
    Kirkbride, James B.
    Pringle, Dennis G.
    Russell, Vincent
    O'Callaghan, Eadbhard
    Waddington, John L.
    SCHIZOPHRENIA RESEARCH, 2014, 152 (01) : 152 - 157
  • [10] The effects of tobacco smoking on age of onset of psychosis and psychotic symptoms in a first-episode psychosis population
    Hickling, Lauren M.
    Ortiz-Garcia de la Foz, Victor
    Ayesa-Arriola, Rosa
    Crespo-Facorro, Benedicto
    McGuire, Philip
    Perez-Iglesias, Rocio
    ADDICTION, 2017, 112 (03) : 526 - 532