Recombination at double-strand breaks and DNA ends: Conserved mechanisms from phage to humans

被引：257
|
作者：
Cromie, GA [1 ]
Connelly, JC [1 ]
Leach, DRF [1 ]
机构：
[1] Univ Edinburgh, Inst Cell & Mol Biol, Edinburgh EH9 3JR, Midlothian, Scotland
来源：
MOLECULAR CELL | 2001年 / 8卷 / 06期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/S1097-2765(01)00419-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The recombination mechanisms that deal with double-strand breaks in organisms as diverse as phage, bacteria, yeast, and humans are remarkably conserved. We discuss conservation in the biochemical pathways required to recombine DNA ends and in the structure of the DNA products. In addition, we highlight that two fundamentally distinct broken DNA substrates exist and describe how they are repaired differently by recombination. Finally, we discuss the need to coordinate recombinational repair with cell division through DNA damage response pathways.
引用
收藏
页码：1163 / 1174
页数：12
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