Expeditious synthesis of novel NK1 antagonists based on a 1,2,4-trisubstituted cyclohexane

被引：8
|
作者：
Dirat, O [1 ]
Elliott, JM [1 ]
Jelley, RA [1 ]
Jones, AB [1 ]
Reader, M [1 ]
机构：
[1] Merck Sharp & Dohme Res Labs, Ctr Res Neurosci, Dept Med Chem, Harlow CM20 2QR, Essex, England
来源：
TETRAHEDRON LETTERS | 2006年 / 47卷 / 08期
关键词：
NK1; asymmetric synthesis; triazole; alpha-arylation;
D O I：
10.1016/j.tetlet.2005.12.067
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A stereoselective asymmetric route to novel potent NK1 antagonists based on a 1.2,4-trisubstituted cyclohexane core is discussed. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1295 / 1298
页数：4
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