The availability and use of crop protectants including azoxystrobin in combination with fumigation has extended the Central Wisconsin effective growing season by 2 to 4 weeks. This study, evaluating the influence of these crop protection practices on the optimum nitrogen rate and time of application for Russet Burbank potato (Solanum tuberosum L.), was established as two 3-year field trials designed as split-split plot experiments. Both experiments used metam sodium as the main plots and fungicide treatment (chlorothalonil Zn alone or chlorothalonil Zn alternated with azoxystrobin for the first six sprays) as the first split. In-season fertilizer N rate (179, 224, 269, or 313 kg N ha(-1)) or in-season N timing (N split into two, three, or four applications at 269 kg N ha(-1)) was the second split. Not fumigating resulted in significantly higher verticillium ratings and severely repressed crop yield and tuber quality responses to both fungicide treatment and N rate. On average, fumigation increased total yield 13.6 Mg ha(-1)yr(-1), U.S. No. 1 tubers by 9 % and U.S. No. 1 tubers > 170 g by 5 % over where fumigation was not used. In 2 of the 3 years when azoxystrobin was included in the fungicide program early blight severity was reduced by about 50 %, and on fumigated areas yields were increased 4.8 Mg ha(-1), whereas no yield increase was seen from this fungicide treatment on the non-fumigated plots. In these same years, fumigation increased optimum N rate by about 50 kg ha(-1); however, there was no apparent interaction with fungicide treatment. Although fumigation, fungicide treatment, and time of N application each influenced tuber yield or tuber quality in some years, in the two more responsive years some interactions between these factors were statistically significant, with benefits generally only seen where plots were fumigated.