Anxiolytic activity of endogenous nootropic dipeptide cycloprolylglycine in elevated plus-maze test

被引：16
|
作者：
Gudasheva, TA [1 ]
Konstantinopol'skii, MA [1 ]
Ostrovskaya, RU [1 ]
Seredenin, SB [1 ]
机构：
[1] Russian Acad Med Sci, Inst Pharmacol, Moscow 109801, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 131卷 / 05期
关键词：
cycloprolylglycine; anxiolytic activity; elevated plus-maze;
D O I：
10.1023/A:1017928116025
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Testing in an elevated plus-maze revealed dose-dependent anxiolytic activity of piracetam analog cycloprolylglycine. Intraperitoneal injection of this agent (0.05 mg/kg) 9-fold prolonged the time spent in open arms compared to the control, without affecting the total motor activity. This effect was stereo-selective: D-enantiomer in doses of 0.05 and 0.1 mg/kg was inactive. Therefore, cycloprolylglycine is similar to piracetam in not only nootropic, but also anxiolytic activity. The existence of an endogenous system responsible for the co-regulation of memory and anxiety is hypothesized.
引用
收藏
页码：464 / 466
页数：3
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