Two new 2-arylbenzofurnan derivatives from the leaves of Morus alba

被引：13

作者：

Wu, Xuewei ^{[1
]}

Li, Ming ^{[1
]}

Wang, Xiaoning ^{[1
]}

Shen, Tao ^{[1
]}

Wang, Shuqi ^{[1
]}

Ren, Dongmei ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Dept Nat Prod Chem, Key Lab Chem Biol,Minist Educ, Jinan, Shandong, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Morus alba; leaves; 2-arybenzofuran derivatives; cytotoxicity; EXTRACT;

D O I：

10.1080/14786419.2018.1443095

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new 2-arylbenzofuran derivatives, moracinfurol A and B (1-2), and ten known compounds (3-12) were isolated from the leaves of Morus alba. Their structures were determined on the basis of spectroscopic analysis including 1D, 2D NMR and HR-ESI-MS. All of the 2-arylbenzofuran derivatives were evaluated for cytotoxicity against A549 cells. Some cytotoxic 2-arylbenzofuran derivatives might induce autophagy characterized by the accumulation of LC-3 II.

引用

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页码：204 / 211

页数：8

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