Retrograde signaling by endocannabinoids

被引:159
|
作者
Kreitzer, AC [1 ]
Regehr, WG [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA
关键词
D O I
10.1016/S0959-4388(02)00328-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Recent studies suggest that endocannabinoids act as retrograde messengers at many synapses in the central nervous system. Activation of phospholipases, either through calcium-mediated or receptor-mediated signaling, leads to the formation and release of endocannabinoids. These lipophilic signaling molecules diffuse to nearby presynaptic terminals where they bind to specific G-protein-coupled receptors and inhibit neurotransmitter release for tens of seconds. Thus, an important physiological role of endocannabinoids may be to provide a mechanism by which neurons can rapidly regulate the strength of their synaptic inputs.
引用
收藏
页码:324 / 330
页数:7
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