Combined inhibition of C5 and CD14 attenuates organ inflammation in porcine Escherichia coli sepsis

被引:0
|
作者
Egge, K. H. [1 ]
Thorgersen, E. B. [1 ]
Lindstad, J. K. [1 ]
Pharo, A. M. [1 ]
Bongoni, A. K. [2 ]
Rieben, R. [2 ]
Barratt-Due, A. [1 ]
Mollnes, T. E. [1 ,3 ]
机构
[1] Univ Oslo, Rikshosp, Inst Immunol, N-0027 Oslo, Norway
[2] Univ Bern, Dept Clin Res, Bern, Switzerland
[3] Univ Tromso, Nordland Hosp, Res Lab, Fac Hlth Sci, Bodo Tromso, Norway
关键词
D O I
10.1016/j.molimm.2013.05.027
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:246 / 246
页数:1
相关论文
共 50 条
  • [1] Organ inflammation in porcine Escherichia coli sepsis is markedly attenuated by combined inhibition of C5 and CD14
    Egge, Kjetil H.
    Thorgersen, Ebbe B.
    Pischke, Soren E.
    Lindstad, Julie K.
    Pharo, Anne
    Bongoni, Anjan K.
    Rieben, Robert
    Nunn, Miles A.
    Barratt-Due, Andreas
    Mollnes, Tom E.
    IMMUNOBIOLOGY, 2015, 220 (08) : 999 - 1005
  • [2] Systemic CD14 Inhibition Attenuates Organ Inflammation in Porcine Escherichia coli Sepsis
    Thorgersen, Ebbe Billmann
    Pischke, Soren Erik
    Barratt-Due, Andreas
    Fure, Hilde
    Lindstad, Julie Katrine
    Pharo, Anne
    Hellerud, Bernt Christian
    Mollnes, Tom Eirik
    INFECTION AND IMMUNITY, 2013, 81 (09) : 3173 - 3181
  • [3] Combined Inhibition of Complement (C5) and CD14 Markedly Attenuates Inflammation, Thrombogenicity, and Hemodynamic Changes in Porcine Sepsis
    Barratt-Due, Andreas
    Thorgersen, Ebbe B.
    Egge, Kjetil
    Pischke, Soren
    Sokolov, Andrey
    Hellerud, Bernt C.
    Lindstad, Julie K.
    Pharo, Anne
    Bongoni, Anjan K.
    Rieben, Robert
    Nunn, Miles
    Scott, Helge
    Mollnes, Tom E.
    JOURNAL OF IMMUNOLOGY, 2013, 191 (02): : 819 - 827
  • [4] Combined inhibition of complement (C5) and CD14 markedly attenuates blood thrombogenicity, inflammation and hemodynamic changes in porcine sepsis
    Barratt-Duel, Andreas
    Thorgersen, Ebbe Billmann
    Egge, Kjetil
    Pischke, Soren
    Sokolov, Andrey
    Hellerud, Bernt Christian
    Lindstad, Julie Katrine
    Pharo, Anne
    Nunn, Miles
    Scott, Helge
    Mollnes, Tom Eirik
    IMMUNOBIOLOGY, 2012, 217 (11) : 1152 - 1152
  • [5] Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis
    Bernt C. Hellerud
    Hilde L. Orrem
    Knut Dybwik
    Søren E. Pischke
    Andreas Baratt-Due
    Albert Castellheim
    Hilde Fure
    Grethe Bergseth
    Dorte Christiansen
    Miles A. Nunn
    Terje Espevik
    Corinna Lau
    Petter Brandtzæg
    Erik W. Nielsen
    Tom E. Mollnes
    Journal of Intensive Care, 5
  • [6] Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis
    Hellerud, Bernt C.
    Orrem, Hilde L.
    Dybwik, Knut
    Pischke, Soren E.
    Baratt-Due, Andreas
    Castellheim, Albert
    Fure, Hilde
    Bergseth, Grethe
    Christiansen, Dorte
    Nunn, Miles A.
    Espevik, Terje
    Lau, Corinna
    Brandtzaeg, Petter
    Nielsen, Erik W.
    Mollnes, Tom E.
    JOURNAL OF INTENSIVE CARE, 2017, 5
  • [7] Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome
    Thomas, Anub Mathew
    Schjalm, Camilla
    Nilsson, Per H.
    Lindenskov, Paal H. H.
    Rortveit, Runa
    Solberg, Ronnaug
    Saugstad, Ola Didrik
    Berglund, Magnus M.
    Stromberg, Patrik
    Lau, Corinna
    Espevik, Terje
    Jansen, Johan Hogset
    Castellheim, Albert
    Mollnes, Tom Eirik
    Barratt-Due, Andreas
    NEONATOLOGY, 2018, 113 (04) : 322 - 330
  • [8] Dual inhibition of complement C5 and CD14 attenuates inflammation in a cord blood model
    Aline U. Bjerkhaug
    Hildegunn N. Granslo
    Jorunn Pauline Cavanagh
    Ina Høiland
    Judith Krey Ludviksen
    Corinna Lau
    Terje Espevik
    Tom Eirik Mollnes
    Claus Klingenberg
    Pediatric Research, 2023, 94 : 512 - 519
  • [9] Dual inhibition of complement C5 and CD14 attenuates inflammation in a cord blood model
    Bjerkhaug, Aline U.
    Granslo, Hildegunn N.
    Cavanagh, Jorunn Pauline
    Hoiland, Ina
    Ludviksen, Judith Krey
    Lau, Corinna
    Espevik, Terje
    Mollnes, Tom Eirik
    Klingenberg, Claus
    PEDIATRIC RESEARCH, 2023, 94 (02) : 512 - 519
  • [10] Simultaneous C5 and CD14 inhibition limits inflammation and organ dysfunction in pig polytrauma
    Lupu, Ludmila
    Horst, Klemens
    Greven, Johannes
    Mert, Uemit
    Ludviksen, Judith A. K.
    Pettersen, Kristin
    Lau, Corinna
    Li, Yang
    Palmer, Annette
    Qin, Kang
    Zhang, Xing
    Mayer, Benjamin
    van Griensven, Martijn
    Huber-Lang, Markus
    Hildebrand, Frank
    Mollnes, Tom Eirik
    FRONTIERS IN IMMUNOLOGY, 2022, 13 : 952267