Organophosphate hydrolase - an enzyme catalyzing degradation of phosphorus-containing toxins and pesticides

被引：52
|
作者：
Efremenko, EN [1 ]
Sergeeva, VS [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119899, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2001年 / 50卷 / 10期
关键词：
organophosphate hydrolase; mechanism of enzymatic catalysis; organophosphorus neurotoxins; amines; substrate specificity; inhibitors;
D O I：
10.1023/A:1014377912147
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The available investigations on the structure and properties of the enzyme organophosphate hydrolase exhibiting catalytic activity with respect to orthophosphates are reviewed. Recent data on the mechanism of enzymatic hydrolysis of paraoxon are surveyed. The role of two metal ions involved in the enzyme active site is considered. The substrate specificity and the influence of various inhibitors on the kinetic characteristics of the enzyme are discussed.
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页码：1826 / 1832
页数：7
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