Design, synthesis, and SAR of focal adhesion kinase (FAK) inhibitors

被引：0
|
作者：
Roberts, Walter Gregory
Berliner, Martin
Coleman, Kevin
Emerson, Erling
Griffor, Matt
Hulford, Catherine
Jani, Jitesh
Kath, John
LaGreca, Susan
Lin, Jing
Lorenzen, Marianne J.
Marr, Eric
Martinez-Alsina, Luis
Patel, Nandini
Richter, Daniel
Roberts, Erika
Autry, Christopher
Ung, Ethan
Felix, Vajdos
Vetelino, Beth
Wessel, Matthew
Whalen, Pamela
Xu, Huiping
Yao, Lili
机构：
来源：
MOLECULAR CANCER THERAPEUTICS | 2009年 / 8卷 / 12期
关键词：
D O I：
10.1158/1535-7163.TARG-09-A86
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A86
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Identification and synthesis of benzimidazole carboxamides as potent inhibitors of focal adhesion kinase (FAK)
    Verma, Sharad K.
    Leber, Jack D.
    LaFrance, Louis V.
    Li, Mei
    Duquenne, Celine
    Cui, Guanglei
    Miller, William H.
    CANCER RESEARCH, 2011, 71
  • [2] Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma
    Li, Bo
    Li, Yongliang
    Tomkiewicz-Raulet, Celine
    Dao, Pascal
    Lietha, Daniel
    Yen-Pon, Expedite
    Du, Zhiyun
    Coumoul, Xavier
    Garbay, Christiane
    Etheve-Quelquejeu, Melanie
    Chen, Huixiong
    JOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (21) : 12707 - 12724
  • [3] Design, synthesis and activity of inhibitors of focal adhesion kinase.
    Luzzio, MJ
    Autry, CL
    Bhattacharya, SK
    Cooper, BA
    Griffor, M
    Hinez, T
    Hulford, CA
    Kath, JC
    Marr, E
    Richter, DT
    Roberts, WG
    Ung, E
    Vajdos, F
    Whalen, P
    CLINICAL CANCER RESEARCH, 2005, 11 (24) : 9051S - 9051S
  • [4] Progress in the Development of Small Molecular Inhibitors of Focal Adhesion Kinase (FAK)
    Lu, Yang
    Sun, Haiying
    JOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (23) : 14382 - 14403
  • [5] Identification of potential focal adhesion kinase (FAK) inhibitors: a molecular modeling approach
    Nadar, Sahaya
    Borkar, Maheshkumar R.
    Khan, Tabassum
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2024,
  • [6] Focal adhesion kinase (FAK), a multifunctional protein
    Cornillon, J
    Campos, L
    Guyotat, D
    M S-MEDECINE SCIENCES, 2003, 19 (6-7): : 743 - 752
  • [7] Design, synthesis, activity and properties of selective inhibitors of focal adhesion kinase.
    Luzzio, Michael J.
    Autry, Christopher
    Cooper, Beth
    Griffor, Matt
    Hulford, Catherine
    Kath, John
    Lin, Jing
    Marr, Eric
    Richter, Daniel
    Roberts, W. Gregory
    Ung, Ethan
    Vajdos, Felix
    Wessel, Mathew
    Whalen, Pamela
    Yao, Lili
    CANCER RESEARCH, 2006, 66 (08)
  • [8] Targeting focal adhesion kinase (FAK) for cancer therapy: FAK inhibitors, FAK-based dual-target inhibitors and PROTAC degraders
    Yang, Ming
    Xiang, Hua
    Luo, Guoshun
    BIOCHEMICAL PHARMACOLOGY, 2024, 224
  • [9] Oncogenic Receptor Tyrosine Kinases Directly Phosphorylate Focal Adhesion Kinase (FAK) as a Resistance Mechanism to FAK-Kinase Inhibitors
    Marlowe, Timothy A.
    Lenzo, Felicia L.
    Figel, Sheila A.
    Grapes, Abigail T.
    Cance, William G.
    MOLECULAR CANCER THERAPEUTICS, 2016, 15 (12) : 3028 - 3039
  • [10] Design, synthesis, and biological evaluation of novel covalent inhibitors targeting focal adhesion kinase
    Chen, Tao
    Liu, Yan
    Shi, Mingsong
    Tang, Minghai
    Si, Wenting
    Yuan, Xue
    Wen, Yi
    Chen, Lijuan
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 54
12345