Efficient Chromium(II)-Catalyzed Cross-Coupling Reactions between Csp2 Centers

被引：119
|
作者：
Steib, Andreas K. [1 ]
Kuzmina, Olesya M. [1 ]
Fernandez, Sarah [1 ]
Flubacher, Dietmar [2 ]
Knochel, Paul [1 ]
机构：
[1] Univ Munich, Dept Chem, D-81377 Munich, Germany
[2] Novartis Pharma AG, CH-4056 Basel, Switzerland
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 41期
基金：
欧洲研究理事会;
关键词：
ARYL GRIGNARD-REAGENTS; CARBON BOND-FORMATION; CATALYTIC C-C; FUNCTIONALIZED ARYLMAGNESIUM; HETEROARYL HALIDES; IRON; COBALT; COPPER; CHLORIDE; MAGNESIUM;
D O I：
10.1021/ja409076z
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Low-toxicity chromium(II) chloride catalyzes at 25 degrees C within minutes the coupling reactions of various (hetero)arylmagnesium reagents with N-heterocyclic halides, aromatic halogenated ketones or imines, and alkenyl iodides. Remarkably, much lower amounts of homo-coupling side products are obtained compared to related iron, cobalt, or manganese cross-couplings.
引用
收藏
页码：15346 / 15349
页数：4
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