pH-responsive PEG-poly(β-amino ester) block copolymer micelles with a sharp transition

被引：92

作者：

Kim, MS

Hwang, SJ

Han, JK

Choi, EK

Park, HJ

Kim, JS

Lee, DS ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Dept Polymer Sci & Engn, Suwon 440746, South Korea

[2] Univ Ulsan, Dept Radiat Oncol, Ulsan 680749, South Korea

[3] Inha Univ, Coll Med, Dept Microbiol, Inchon 402751, South Korea

[4] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2006年 / 27卷 / 06期

关键词：

block copolymers; micelles; pH-sensitive polymer; pKb value; polymeric rnicelle; poly(beta-amino esters);

D O I：

10.1002/marc.200500769

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A pH-sensitive block copolymer is synthesized by step polymerization and its pH-sensitive micellization-demicellization behavior is studied. This polymer has a hydrophilic MPEG (shell) and hydrophobic but pH-sensitive poly(beta-amino ester) (core), which can form a self-assembled micelle. As confirmed by fluorescence spectroscopy and dynamic light scattering (DLS), this polymer shows a sharp pH-sensitive micellization-demicellization behavior. It is confirmed that the pH sensitivity is affected by the molecular weight ratio between the MPEG and poly(beta-amino ester).

引用

页码：447 / 451

页数：5

共 50 条

[1] Synthesis and Characterization of pH-Responsive PEG-Poly(β-Amino Ester) Block Copolymer Micelles as Drug Carriers to Eliminate Cancer Stem Cells
Li, Weinan
Sun, Jialin
Zhang, Xiaoyu
Jia, Li
Qiao, Mingxi
Zhao, Xiuli
Hu, Haiyang
Chen, Dawei
Wang, Yanhong
PHARMACEUTICS, 2020, 12 (02)
[2] pH-sensitivity control of PEG-poly(β-amino ester) block copolymer micelle
Su Jong Hwang
Min Sang Kim
Jong Kwon Han
Doo Sung Lee
Bong Sup Kim
Eun Kyung Choi
Heon Joo Park
Jin Seok Kim
Macromolecular Research, 2007, 15 : 437 - 442
[3] pH-Sensitivity control of PEG-Poly(β-amino ester) block copolymer micelle
Hwang, Su Jong
Kim, Min Sang
Han, Jong Kwon
Lee, Doe Sung
Kim, Bong Sup
Choi, Eun Kyung
Park, Heon Joe
Kim, An Seek
MACROMOLECULAR RESEARCH, 2007, 15 (05) : 437 - 442
[4] Micelles of enzymatically synthesized PEG-poly(amine-co-ester) block copolymers as pH-responsive nanocarriers for docetaxel delivery
Zhang, Xiaofang
Liu, Bo
Yang, Zhe
Zhang, Chao
Li, Hao
Luo, Xingen
Luo, Huiyan
Gao, Di
Jiang, Qing
Liu, Jie
Jiang, Zhaozhong
COLLOIDS AND SURFACES B-BIOINTERFACES, 2014, 115 : 349 - 358
[5] PEG-poly(amino acid) Block Copolymer Micelles for Tunable Drug Release
Andrei Ponta
Younsoo Bae
Pharmaceutical Research, 2010, 27 : 2330 - 2342
[6] PEG-poly(amino acid) Block Copolymer Micelles for Tunable Drug Release
Ponta, Andrei
Bae, Younsoo
PHARMACEUTICAL RESEARCH, 2010, 27 (11) : 2330 - 2342
[7] Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly (β-amino ester) block copolymer micelles for cancer therapy
Ko, Jinyoung
Park, Kyeongsoon
Kim, Yoo-Shin
Kim, Min Sang
Han, Jong Kwon
Kim, Kwangmeyung
Park, Rang-Woon
Kim, In-San
Song, Hyun Kyu
Lee, Doo Sung
Kwon, Ick Chan
JOURNAL OF CONTROLLED RELEASE, 2007, 123 (02) : 109 - 115
[8] Self-assembled pH-responsive pluronic P123-poly(β-amino ester) copolymer micelles for cancer therapy
Cai, Xiao Qing
Zhai, Guangxi
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2016, 12 (02) : 552 - 552
[9] pH-responsive copolymers based on pluronic P123-poly(β-amino ester): Synthesis, characterization and application of copolymer micelles
Cai, Xiaoqing
Liu, Mengrui
Zhang, Chen
Sun, Deqing
Zhai, Guangxi
COLLOIDS AND SURFACES B-BIOINTERFACES, 2016, 142 : 114 - 122
[10] Drug Release Patterns and Cytotoxicity of PEG-poly(aspartate) Block Copolymer Micelles in Cancer Cells
Eckman, Allison M.
Tsakalozou, Eleftheria
Kang, Nayon Y.
Ponta, Andrei
Bae, Younsoo
PHARMACEUTICAL RESEARCH, 2012, 29 (07) : 1755 - 1767

← 1 2 3 4 5 →