Vitamin D as a marker of cognitive decline in elderly Indian population

被引：9
|
作者：
Vedak, Tejal Kanhaiya [1 ]
Ganwir, Vaishali [2 ]
Shah, Arun B. [2 ]
Pinto, Charles [3 ]
Lele, Vikram R. [4 ]
Subramanyam, Alka [3 ]
Shah, Hina [2 ]
Deo, Sudha Shrikant [1 ,2 ]
机构：
[1] Sir HN Med Res Soc, Appl Biol Immunol, Mumbai 400004, Maharashtra, India
[2] Sir HN Med Res Soc, Mumbai 400004, Maharashtra, India
[3] Sir HN Med Res Soc, Psychiat, Mumbai 400004, Maharashtra, India
[4] Sir HN Med Res Soc, Nucl Med, Mumbai 400004, Maharashtra, India
来源：
ANNALS OF INDIAN ACADEMY OF NEUROLOGY | 2015年 / 18卷 / 03期
关键词：
Cognitive decline; dementia; homocysteine; MMSE score; vitamin D; HIGHLY EDUCATED INDIVIDUALS; HOMOCYSTEINE LEVELS; ALZHEIMERS-DISEASE; DEMENTIA; METAANALYSIS; DYSFUNCTION; DEFICIENCY; BRAIN; STATE; RISK;
D O I：
10.4103/0972-2327.160052
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objectives: Very few studies in India have addressed the role of vitamin D in cognitive function. The present study was conducted to assess the serum levels of 25-hydroxyvitamin D (25(OH) D) and its association with markers of cognitive impairment and homocysteine levels in the elderly Indian population. Materials and Methods: The study population consisted of patients with dementia (Group A, n = 32), mild cognitive impairment (MCI; Group B, n = 24), and elderly age-matched controls (Group C, n = 30). Measurement of serum levels of 25(OH) D and total homocysteine were done. Results: Significant decreased concentration of 25(OH) D and increased concentration of homocysteine was observed. Association of serum levels of vitamin D with markers of cognitive decline as well as serum homocysteine levels was observed in patients with dementia and MCI when compared to controls. Conclusion: Correlation of vitamin D with markers of cognitive decline and homocysteine opens a new door for early diagnosis of cognitive impairment.
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收藏
页码：314 / 319
页数：6
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