Synthesis and antinephritic activities of quinoline-3-carboxamides and related compounds

被引：28
|
作者：
Tsuji, K
Spears, GW
Nakamura, K
Tojo, T
Seki, N
Sugiyama, A
Matsuo, M
机构：
[1] Fujisawa Pharmaceut Co Ltd, Med Chem Res Labs, Yodogawa Ku, Osaka 5328514, Japan
[2] Fujisawa Pharmaceut Co Ltd, Res Informat Management, Yodogawa Ku, Osaka 5328514, Japan
[3] Fujisawa Pharmaceut Co Ltd, Exploratory Res Labs, Tsukuba, Ibaraki 3002698, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 01期
关键词：
D O I：
10.1016/S0960-894X(01)00671-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of linomide-related quinoline-3-carboxamides and their analogues was prepared and evaluated for antinephritic activities. The 6-MeS derivative 7a was highly effective in two nephritis models, namely chronic graft-versus-host disease and autoimmune MRL/1 mice. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：85 / 88
页数：4
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