Emphysema and Mechanical Stress-Induced Lung Remodeling

被引：63

作者：

Suki, Bela ^{[1
]}

Sato, Susumu ^{[1
]}

Parameswaran, Harikrishnan ^{[1
]}

Szabari, Margit V. ^{[1
]}

Takahashi, Ayuko ^{[1
]}

Bartolak-Suki, Erzsebet ^{[1
]}

机构：

[1] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA

来源：

PHYSIOLOGY | 2013年 / 28卷 / 06期

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; ELASTASE-INDUCED EMPHYSEMA; SUPEROXIDE DISMUTASE PROTECTS; EXTRACELLULAR-MATRIX; OXIDATIVE FRAGMENTATION; IN-VITRO; COLLAGEN; FORCES; INFLAMMATION; CELLS;

D O I：

10.1152/physiol.00041.2013

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Transpulmonary pressure and the mechanical stresses of breathing modulate many essential cell functions in the lung via mechanotransduction. We review how mechanical factors could influence the pathogenesis of emphysema. Although the progression of emphysema has been linked to mechanical rupture, little is known about how these stresses alter lung remodeling. We present possible new directions and an integrated multiscale view that may prove useful in finding solutions for this disease.

引用

页码：404 / 413

页数：10

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