Acyclic and cyclic thioenamino peptides: solution- and solid-phase synthesis

被引：10

作者：

Goren, Lee ^{[1
]}

Pappo, Doron ^{[1
]}

Goldberg, Israel ^{[1
]}

Kashman, Yoel ^{[1
]}

机构：

[1] Tel Aviv Univ, Sch Chem, IL-69978 Ramat Aviv, Israel

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 09期

关键词：

Cyclic peptides; Solid-phase synthesis; FGly; Endiamine; Thioenamine; HORMONE VASOPRESSIN; ANALOGS; TURNS; DIKETOPIPERAZINES; CONFORMATIONS; DESMOPRESSIN; MIMETICS; DESIGN;

D O I：

10.1016/j.tetlet.2008.12.072

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Seven- and 10-membered cyclic thioenamino peptides, that is, 1,4-thiazepinone (11) and cyclic thioenamino peptide 9 (which represents a potential gamma-turn mimetic), were synthesized, and the structure of 11 was secured by X-ray diffraction analysis of its TFA salt. The aforementioned compounds were prepared in solution and by solid-phase synthesis. Additionally, we have prepared thioenamino diketopiperazine synthon 16. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1048 / 1050

页数：3

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