Stability Study of Novel Medicated Hydrogel Wound Dressings

被引：16
|
作者：
Roy, Niladri [1 ]
Saha, Nabanita [1 ]
Saha, Petr [1 ]
机构：
[1] Tomas Bata Univ Zlin, Ctr Polymer Syst, Zlin 76001, Czech Republic
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2013年 / 62卷 / 03期
关键词：
Biomaterials; boric acid; hydrogels; stability; wound dressing; POLY(VINYL ALCOHOL) HYDROGEL; IN-VITRO; BIOCOMPATIBILITY; RELEASE; BIOMATERIALS; DRUG;
D O I：
10.1080/00914037.2011.641697
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
PVP-CMC and PVP-CMC-BA hydrogels were prepared for biomedical applications. These hydrogels were stored under 5 degrees C +/- 2 degrees C, 22 degrees C +/- 3 degrees C, and 40 degrees C for 180 days to identify their suitable storage condition. At 5 degrees C +/- 2 degrees C, hydrogels showed minimum alteration in physical properties. No microbial colonies appeared on PVP-CMC stored at 5 degrees C +/- 2 degrees C, but they slowly appeared at 22 degrees C +/- 3 degrees C and 40 degrees C after 45 days. FTIR and antibacterial assay demonstrated that boric acid (BA) in hydrogel remained stable for 180 days. PVP-CMC-BA is more bio-stable than PVP-CMC because of BA, an antibacterial agent. Finally, 5 degrees C +/- 2 degrees C was recommended as the best storage condition for both PVP-CMC and PVP-CMC-BA hydrogels.
引用
收藏
页码：150 / 156
页数：7
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