Efficient Preparation of Imidazo[1,5-a]pyridine-1-carboxylic Acids

被引：8

作者：

Tverdiy, Dmytro O. ^{[1
,2
,3
]}

Chekanov, Maksym O. ^{[1
]}

Savitskiy, Pavlo V. ^{[1
]}

Syniugin, Anatolii R. ^{[1
]}

Yarmoliuk, Sergiy M. ^{[1
]}

Fokin, Andrey A. ^{[2
]}

机构：

[1] Inst Mol Biol & Genet NAS Ukraine, Dept Med Chem, 150 Zabolotnogo Str, UA-03143 Kiev, Ukraine

[2] Natl Tech Univ Ukraine, Kiev Polytech Inst, Dept Organ Chem, 37 Peremohy Ave, UA-03056 Kiev, Ukraine

[3] Azepine Ltd, Suite 7777,6 Slington House,Rankine Rd, Basingstoke RG24 8PH, Hants, England

来源：

SYNTHESIS-STUTTGART | 2016年 / 48卷 / 23期

关键词：

amides; cyclization; heterocycles; bicyclic compounds; acylation; BIOLOGICAL EVALUATION; RECEPTOR ANTAGONISTS; CRIBROSTATIN; 6; AGENTS; DERIVATIVES; INHIBITORS;

D O I：

10.1055/s-0035-1561489

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a novel and efficient approach to the synthesis of imidazo[1,5-a]pyridine-1-carboxylic acids. By using the reaction of 2-(aminomethyl) pyridine with acyl chlorides followed by one-pot treatment with trifluoroacetic anhydride, 2,2,2-trifluoro-1-imidazo[1,5-a]pyridin-1-ylethanones were obtained, which were then converted into imidazo[1,5-a]pyridine-1-carboxylic acids in high preparative yields through haloform cleavage.

引用

页码：4269 / 4277

页数：9

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