Decrease in CD4+CD25+ and CD8+CD28+ T cells in interstitial pneumonitis associated with rheumatic disease

被引：6

作者：

Katagiri, Akira ^{[1
]}

Morimoto, Shinji ^{[1
]}

Nakiri, Yutaka ^{[1
]}

Nakano, Souichiro ^{[1
]}

Mitsuo, Akiko ^{[1
]}

Suzuki, Jun ^{[1
]}

Amano, Hirofumi ^{[1
]}

Nozawa, Kazuhisa ^{[1
]}

Asano, Masanao ^{[1
]}

Tokano, Yoshiaki ^{[1
]}

Hashimoto, Hiroshi ^{[1
]}

Takasaki, Yoshinari ^{[1
]}

机构：

[1] Juntendo Univ, Sch Med, Dept Rheumatol & Internal Med, Bunkyo Ku, Tokyo 1138421, Japan

来源：

MODERN RHEUMATOLOGY | 2008年 / 18卷 / 06期

关键词：

CD4(+)CD25(+) regulatory T cell; CD8(+)CD28(-) suppressor T cell; Interstitial pneumonitis; Rheumatic diseases; CD62L;

D O I：

10.1007/s10165-008-0090-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The expression of CD25 or CD28 on T cells was examined in patients with rheumatic diseases associated with interstitial pneumonitis (IP), in order to investigate the conditions of CD4(+)CD25(+) regulatory T cells and CD8(+)CD28(-) suppressor T cells. Fifty-five patients with various rheumatic diseases and 23 normal controls were enrolled. CD4(+)CD25(+) T cells of patients with IP were significantly decreased in comparison with non-IP patients, and the ratio of CD8(+)CD28(-) T cells in patients with IP was significantly higher than that in non-IP patients or normal controls. These results for CD8(+)CD28(-) T cells were in accord with the decrease in CD8(+)CD28(+) T cells, and may be related to activation-induced CD8(+)CD28(+) T-cell death. Thus, the abnormality of CD4(+)CD25(+) regulatory T cells may be related to the pathogenesis of IP, and the survival and activation of CD8(+)T cells.

引用

页码：562 / 569

页数：8

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