This meta-analysis summarized the relations between social network site use and neuroticism, extraversion, openness, agreeableness and conscientiousness. Sixty-one articles comprising 67 independent samples (N = 22,899 participants) were identified. The overall correlations of social network site use with neuroticism ((r) over bar = 0.08) and extraversion ((r) over bar = 0.09) were about positively small, while conscientiousness had a negative and quite small correlation with social network site use with (r) over bar = -0.04. Openness and agreeableness were not significantly correlated with social network site use with (r) over bar = -0.01. The effects of most moderators, including publication outlet, site participants spent time, scale of time spent, indicator of social network site use, Big Five measure, and participant age were not significant. In contrast, the effects of country where the study was conducted and participant gender were mixed.