Imatinib Mesylate in the Treatment of Diffuse Cutaneous Mastocytosis

被引：25

作者：

Morren, Marie-Anne ^{[1
]}

Hoppe, Anne ^{[4
]}

Renard, Marleen ^{[2
]}

Rychter, Maria Debiec ^{[3
]}

Uyttebroeck, Anne ^{[2
]}

Dubreuil, Patrice ^{[6
]}

Martin, Ludovic ^{[5
]}

机构：

[1] Katholieke Univ Leuven, Dept Dermatol, Louvain, Belgium

[2] Katholieke Univ Leuven, Dept Pediat Hematol & Oncol, Louvain, Belgium

[3] Katholieke Univ Leuven, Dept Human Genet, Louvain, Belgium

[4] Univ Hosp Angers, Dept Pediat, Angers, France

[5] Univ Hosp Angers, Dept Dermatol, Angers, France

[6] Inst J Paoli I Calmettes, INSERM, U119, F-13009 Marseille, France

来源：

JOURNAL OF PEDIATRICS | 2013年 / 162卷 / 01期

关键词：

KINASE INHIBITORS; KIT MUTATION; SITE;

D O I：

10.1016/j.jpeds.2012.08.035

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Diffuse cutaneous mastocytosis is a less common but potentially life-threatening variant of childhood mastocytosis. Here we report 2 children with diffuse cutaneous mastocytosis in whom an activating somatic KIT mutation was detected. Treatment with imatinib, a KIT inhibitor, resulted in resolution of the lesions and were well tolerated by the patients. (J Pediatr 2013;162:205-7).

引用

页码：205 / 207

页数：3

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