The Urinary Microbiome: Implications in Bladder Cancer Pathogenesis and Therapeutics

被引：56
|
作者：
Bajic, Petar [1 ]
Wolfe, Alan J. [2 ]
Gupta, Gopal N. [1 ,3 ,4 ]
机构：
[1] Loyola Univ Chicago, Stritch Sch Med, Dept Urol, 2160 S First Ave,Bldg 54,Room 237A, Maywood, IL 60153 USA
[2] Loyola Univ Chicago, Stritch Sch Med, Dept Microbiol & Immunol, Maywood, IL 60153 USA
[3] Loyola Univ Chicago, Stritch Sch Med, Dept Surg, Maywood, IL 60153 USA
[4] Loyola Univ Chicago, Stritch Sch Med, Dept Radiol, Maywood, IL 60153 USA
来源：
UROLOGY | 2019年 / 126卷
关键词：
BACILLUS-CALMETTE-GUERIN; IMMUNOTHERAPY; INCONTINENCE; RECURRENCE; BACTERIA; CELLS; RISK;
D O I：
10.1016/j.urology.2018.12.034
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Recent investigation has proven that the bladder is not sterile. However, the implications of this finding in the pathophysiology and management of urothelial cell carcinoma have not been fully described. In this review, we summarize the literature relating to the urinary and gastrointestinal microbiomes in the context of urothelial cell carcinoma. The bladder microbiome may relate to urothelial cell carcinoma pathogenesis/progression, act as a noninvasive and modifiable urinary biomarker and have implications in treatment using immunotherapy agents such as intravesical bacillus Calmette-Guerin. Investigators should continue to optimize techniques to characterize this intriguing new area of human health. (C) 2019 Elsevier Inc.
引用
收藏
页码：10 / 15
页数：6
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