The inhibitory role of miR-485-5p in colorectal cancer proliferation and invasion via targeting of CD147

被引：9

作者：

Pan, Yuqin ^{[1
]}

Sun, Huiling ^{[1
]}

Hu, Xiuxiu ^{[1
,2
]}

He, Bangshun ^{[1
]}

Liu, Xiangxiang ^{[1
]}

Xu, Tao ^{[1
]}

Chen, Xiaoxiang ^{[1
,2
]}

Zeng, Kaixuan ^{[1
,2
]}

Wang, Shukui ^{[1
,2
]}

机构：

[1] Nanjing Med Univ, Nanjing Hosp 1, Cent Lab, 68 Changle Rd, Nanjing 210006, Jiangsu, Peoples R China

[2] Southeast Univ, Clin Med Coll, Nanjing 210009, Jiangsu, Peoples R China

来源：

ONCOLOGY REPORTS | 2018年 / 39卷 / 05期

基金：

中国国家自然科学基金;

关键词：

miR-485-5p; tumor-suppressing; colorectal cancer; CD147; pathogenesis; CELL-PROLIFERATION; BIOMARKERS; EXPRESSION; CARCINOMA;

D O I：

10.3892/or.2018.6309

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recently, miR-485-5p was identified as a tumor-suppressing microRNA in some human cancers. However, the expression and biological role of miR-485-5p in colorectal cancer (CRC) remain unclear. Herein, we found that the expression of miR-485-5p in CRC tissues and cell lines was much lower than that in the control, respectively. Moreover, the overexpression of miR-485-5p could inhibit the proliferation and invasion of CRC cell lines in vitro and in vivo. Furthermore, we determined that miR-485-5p could decrease the expression of CD147 by directly targeting CD147 3UTR. In addition, the expression of CD147 was inversely correlated with the expression of miR-485-5p in CRC tissues. Collectively, our results revealed that miR-485-5p played a pivotal tumor-suppressing role in CRC through downregulation of cancer-associated gene CD147, and may provide a better understanding of the pathogenesis in CRC and a new bio-target for CRC therapy.

引用

页码：2201 / 2208

页数：8

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