Inclusion volume solid-phase synthesis

被引：9

作者：

Eichler, Jutta ^{[1
]}

Houghten, Richard A. ^{[1
]}

Lebl, Michal ^{[2
]}

机构：

[1] Torrey Pines Inst Mol Studies, San Diego, CA 92121 USA

[2] Selectide Corp, Tucson, AZ USA

来源：

JOURNAL OF PEPTIDE SCIENCE | 1996年 / 2卷 / 04期

关键词：

solid-phase synthesis; peptide synthesis; multiple synthesis; inclusion volume synthesis;

D O I：

10.1002/psc.310020402

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Solid-phase synthesis of peptides was carried out using only the volume of the solvent included in the swollen solid-phase resin beads (inclusion volume synthesis). This approach enables (i) the use of higher concentrations of activated amino acids, resulting in increased coupling rates, (ii) drastically decreased consumption of solvents, and (iii) the construction of multiple peptide synthesizers having virtually no reaction vessels.

引用

页码：240 / 244

页数：5

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