APOPTOSIS INDUCTION OF CENTELLA ASIATICA ON HUMAN BREAST CANCER CELLS

被引：0
|
作者：
Babykutty, Suboj [1 ]
Padikkala, Jose [2 ]
Sathiadevan, Priya Prasanna
Vijayakurup, Vinod
Azis, Thasni Karedath Abdul [3 ]
Srinivas, Priya [3 ]
Gopala, Srinivas [1 ]
机构：
[1] Sree Chitra Tirunal Inst Med Sci & Technol, Dept Biochem, Thiruvananthapuram 695011, Kerala, India
[2] Amala Canc Res Ctr, Trichur 680553, Kerala, India
[3] Rajiv Gandhi Ctr Biotechnol, Div Canc Biol, Thiruvananthapuram 695014, Kerala, India
来源：
AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES | 2009年 / 6卷 / 01期
关键词：
Apoptosis; Cancer; Centella asiatica; TOTAL TRITERPENIC FRACTION; UMBELLIFERAE; EXTRACTS; GROWTH; ACID; RATS;
D O I：
暂无
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
The present study evaluated the ability of methanolic extract of Centella asiatica (Linn) Urban (Umbelliferae) to induce apoptosis in different cancer cell lines. MCF-7 cells emerged as the most sensitive cell line for in vitro growth inhibitory activity. C. asiatica extract induced apoptosis in MCF-7 cells as indicated by nuclear condensation, increased annexin staining, loss of mitochondrial membrane potential and induction of DNA breaks identified by TUNEL reactivity. It is possible that the use of C. asiatica extract as a component in herbal medicines could be justifiable.
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页码：9 / 16
页数：8
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