Haem is associated with thrombosis in neonates and infants undergoing cardiac surgery for congenital heart disease

被引：5
|
作者：
Stolla, M. [1 ,2 ,3 ]
Henrichs, K. [1 ]
Cholette, J. M. [4 ]
Pietropaoli, A. P. [5 ]
Phipps, R. P. [1 ,4 ,5 ,6 ]
Spinelli, S. L. [1 ]
Blumberg, N. [1 ]
机构：
[1] Univ Rochester, Dept Pathol & Lab Med, Rochester, NY USA
[2] Bloodworks NW Res Inst, 921 Terry Ave,Room 408, Seattle, WA 98104 USA
[3] Univ Washington, Dept Med, Div Hematol, Seattle, WA 98195 USA
[4] Univ Rochester, Dept Pediat Crit Care & Cardiol, Rochester, NY USA
[5] Univ Rochester, Dept Med, Div Pulm & Crit Care Med, Rochester, NY USA
[6] Univ Rochester, Environm Med Lung Biol & Dis Program, Rochester, NY USA
来源：
VOX SANGUINIS | 2018年 / 113卷 / 01期
关键词：
hemostasis; red cell components; transfusion; -; pediatrics; surgery; NEUTROPHIL EXTRACELLULAR TRAPS; RED-BLOOD-CELL; STORAGE;
D O I：
10.1111/vox.12606
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
BackgroundHaem levels are associated with thrombosis in a variety of diseases, as well as being a contributing cause of thrombotic events in animal models. Materials and MethodsWe retrospectively analyzed samples from 39 children who underwent cardiac surgery with cardiopulmonary bypass, including 15 children who developed a postoperative thrombosis and 24 controls. ResultsPatients who developed thrombosis postoperatively had statistically significant higher average haem levels over time (presurgery to 12 h postsurgery) compared to patients who did not develop thrombosis. ConclusionHigher cell-free total haem levels are associated with a higher risk of thrombosis in a paediatric cardiac surgical cohort.
引用
收藏
页码：72 / 75
页数：4
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