Absence of Neuronal Autoantibodies in Neuropsychiatric Systemic Lupus Erythematosus

被引：17
|
作者：
Varley, James A. [1 ,2 ]
Andersson, Magnus [3 ]
Grant, Eleanor [1 ,2 ]
Berretta, Antonio [1 ]
Zandi, Michael S. [4 ]
Bondet, Vincent [5 ]
Duffy, Darragh [5 ]
Hunt, David [6 ,7 ]
Piehl, Fredrik [3 ]
Waters, Patrick [1 ]
Irani, Sarosh R. [1 ,2 ]
机构：
[1] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford Autoimmune Neurol Grp, Oxford, England
[2] Oxford Univ Hosp, John Radcliffe Hosp, Dept Neurol, Oxford, England
[3] Karolinska Inst, Karolinska Univ Hosp, Dept Clin Neurosci, Ctr Mol Med, Stockholm, Sweden
[4] Natl Hosp Neurol & Neurosurg, London, England
[5] Inst Pasteur, Immunobiol Dendrit Cells, Inserm U1223, Paris, France
[6] Univ Edinburgh, MRC Inst Genet & Mol Med, Med Res Council MRC, Human Genet Unit,Western Gen Hosp, Edinburgh, Midlothian, Scotland
[7] Univ Edinburgh, Ctr Clin Brain Sci CCBS, Edinburgh, Midlothian, Scotland
来源：
ANNALS OF NEUROLOGY | 2020年 / 88卷 / 06期
基金：
英国惠康基金;
关键词：
RECEPTOR; ANTIBODY;
D O I：
10.1002/ana.25908
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
This study aimed to characterise both neuronal autoantibodies and levels of interferon alpha, two proposed causative agents in neuropsychiatric systemic lupus erythematosus (NPSLE). Cerebrospinal fluid (CSF) and plasma from 35 patients with systemic lupus erythematosus (SLE; 15 with NPSLE) showed no antibodies against natively expressed N-methyl-D-aspartate receptors (NMDARs), or the surface of live hippocampal neurons. By comparison to controls (n = 104), patients with SLE had antibodies that bound to a peptide representing the extracellular domain of NMDARs (p< 0.0001), however, binding was retained against both rearranged peptides and no peptide (r = 0.85 and r = 0.79, respectively,p< 0.0001). In summary, neuronal-surface reactive antibodies were not detected in NPSLE. Further, while interferon alpha levels were higher in SLE (p< 0.0001), they lacked specificity for NPSLE. Our findings mandate a search for novel biomarkers in this condition. ANN NEUROL 2020
引用
收藏
页码：1244 / 1250
页数：7
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