A community-based survey of varicella-zoster virus-specific immune responses in the elderly

被引：29

作者：

Tang, Huamin ^{[2
]}

Moriishi, Eiko ^{[2
]}

Okamoto, Shigefumi ^{[2
]}

Okuno, Yoshinobu ^{[3
]}

Iso, Hiroyasu ^{[4
]}

Asada, Hideo ^{[5
]}

Yamanishi, Koichi

Mori, Yasuko ^{[1
,2
]}

机构：

[1] Kobe Univ, Grad Sch Med, Div Clin Virol, Dept Microbiol & Infect Dis,Chuo Ku, Kobe, Hyogo 6500017, Japan

[2] Natl Inst Biomed Innovat, Lab Virol & Vaccinol, Div Biomed Res, Ibaraki, Japan

[3] Osaka Univ, Res Fdn Microbial Dis, Kagawa, Japan

[4] Osaka Univ, Dept Social & Environm Med, Grad Sch Med, Suita, Osaka, Japan

[5] Nara Med Univ, Dept Dermatol, Sch Med, Kashihara, Nara 634, Japan

来源：

JOURNAL OF CLINICAL VIROLOGY | 2012年 / 55卷 / 01期

关键词：

Varicella-zoster virus; Skin test; Interferon-gamma ELISPOT assay; Cell-mediated immunity; Humoral immunity; CELL-MEDIATED-IMMUNITY; VZV SKIN-TEST; HERPES-ZOSTER; VACCINE; RECIPIENTS; ANTIGEN; DECLINE;

D O I：

10.1016/j.jcv.2012.06.008

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: In the USA, live attenuated varicella-zoster virus (VZV) vaccine is licensed for use in people 50 or older, to reduce the incidence and/or severity of herpes zoster. However, this vaccine is not yet available in Japan, and the immunity profile for VZV in older people has not been investigated in detail in Japan. Objectives: The aim of this study was to conduct a detailed survey about the immunity profile for VZV in older people in Japan. Study design: A panel of immunologic tests (skin test, ELISPOT, gpELISA, IAHA and NT) were used to analyze the immunity to VZV in the subjects. And an interview about zoster history was carried out with each of the subjects. Results: Cellular immunity test (skin test and ELISPOT) results declined with increasing age; on the contrary, humoral immunity test (gpELISA, IAHA and NT) results increased with advancing age. In addition, strongly boosted humoral immunity was found in the subjects with zoster history, however relatively small increase was found in cellular immunity test results. Conclusions: Cell-mediated immunity (CMI) to VZV decreased and humoral immunity increased with increasing age in this population. (C) 2012 Elsevier B. V. All rights reserved.

引用

页码：46 / 50

页数：5

共 50 条

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