Rituximab as an alternative for patients with severe systemic vasculitis refractory to conventional therapy: report of seven cases and literature review

被引：5
|
作者：
da Silva, Leonardo Sales [1 ]
Miranda de Campos, Karla Valeria [2 ]
Guedes de Melo, Ana Karla [2 ]
Soares Egypto de Brito, Danielle Christinne [2 ,3 ,4 ]
Braz, Alessandra Sousa [2 ,3 ,4 ]
Medeiros Freire, Eutilia Andrade [2 ,3 ,4 ]
机构：
[1] Univ Fed Paraiba UFPB, Fac Med, Joao Pessoa, Paraiba, Brazil
[2] Univ Fed Paraiba UFPB, Hosp Univ Lauro Wanderley, Serv Reumatol, Joao Pessoa, Paraiba, Brazil
[3] Univ Fed Paraiba UFPB, Curso Med, Joao Pessoa, Paraiba, Brazil
[4] Univ Fed Paraiba UFPB, Ctr Ciencias Med, Dept Med Interna, Joao Pessoa, Paraiba, Brazil
来源：
REVISTA BRASILEIRA DE REUMATOLOGIA | 2015年 / 55卷 / 06期
关键词：
Rituximab; Systemic vasculitides; Granulomatosis with polyangiitis; Microscopic polyangiitis; Polyarteritis nodosa; GRANULOMATOSIS; POLYANGIITIS;
D O I：
10.1016/j.rbr.2015.07.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The greater understanding of pathophysiology and behavior of systemic vasculitis, together with the development of therapeutic regimens with increasingly better safety and efficacy profiles, dramatically changed the prognosis of patients diagnosed with these clinical entities. Recently, the use of rituximab in the treatment of patients with ANCA-associated vasculitis in randomized clinical trials showed an important alternative in selected cases, especially patients refractory or intolerant to standard therapy with cyclophosphamide and corticosteroids. This article presents the report of seven cases of systemic vasculitis successfully treated with rituximab. (C) 2015 Elsevier Editora Ltda. All rights reserved.
引用
收藏
页码：531 / 535
页数：5
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